EVENT DETAILS AND ABSTRACT

Title: Quantification of NF-kappaB: marriage of genetics, biochemistry and mathematical modeling
Speaker: Andre Levchenko
Speaker Info: Johns Hopkins University
Brief Description:
Special Note: More current information may be available at Plan-it Purple
Abstract:

The NF-kappaB pathway is at the heart of cellular and physiological stress responses. Its activation underlies the life and death decisions on the level of a single cell, being vastly important in understanding of a myriad of diseases, including cancer and auto-immune syndromes. The dynamics of activation of this pathway displays many idiosyncratic and functionally significant characteristics, which were recently addressed by us through iterative and integrative use of a variety of computational and experimental techniques. Among the insights gained was a much deeper understanding of gene regulation by this pathway and its modular organization. In my presentation, I will illustrate the amazing power of computational analysis when it is tightly linked with experimental research, in understanding of this and other signaling phenomena.